Interactive Datasets

Explore our single-cell RNA sequencing, metabolomics, and other datasets

1. Abo, Merritt et al.

a) Download detailed methods and table including clinical details of tissue donors
b) Access interactive shiny web app for single cell RNA sequencing from human AATD lung samples (Figures 1-2)
c) Download .txt file containing code applied to generate Figures (formatted Seurat object available with GSE227210)
d) Download file containing gene lists used to assign cell identity (Figure 1B)
e) Download files containing Hallmark FGSEA with leading edge genes for AT2s (Figure 2A) or AMs (Figure 2E)

2. Werder et al. The American Journal of Human Genetics. 2023

doi:10.1016/j.ajhg.2023.08.017

See the effect of ADGRG6 knockdown on gene expression in iPSC-derived AT2s!

SPRING viewer
Shiny App from Figure 3 (scRNAseq of BU3NGST-CRISPRi iAT2s in 3D +/- ADGRG6 knockdown)

3. Kaserman et al. Cell Reports. 2022

41, 111775

a) Interact with bulk RNA sequencing from syngeneic, CRISPR-edited PiZZ6 ZZ vs MZ vs MM iHeps from Figure 2
b) Interact with metabolomics from syngeneic, CRISPR-edited PiZZ6 ZZ vs MZ vs MM iHeps from Figure 3
c) Interact with scRNAseq data (shiny app of scRNAseq of PiZZ6-ZZ vs PiZZ1-ZZ vs MZ vs MM iHeps) from Figure 5
d) Interact with scRNAseq data (SPRING of scRNAseq of PiZZ6-ZZ vs PiZZ1-ZZ vs MZ vs MM iHeps) from Figure 5

4. Werder et al. Sci Adv. 2022

Jul 15;8(28):eabo6566

See the effect of DSP knockdown on gene expression in iPSC-derived AT2s! SPRING from Figure 4 (scRNAseq of BU3NGST-CRISPRi iAT2s in 3D +/- DSP knockdown)

5. Abo et al. JCI Insight. 2022

Mar 22;7(6):e155589

See the effect of ALI culture or cigarette smoke exposure on your favorite gene in iPSC-derived AT2s! SPRING from Figure 4 (scRNA-seq of SPC2 iAT2s in 3D, 2D, ALI, and smoke-exposed ALI cultures)