Selected Publications

  1. Abo et al. Pulmonary cellular toxicity in alpha-1 antitrypsin deficiency. Chest. 2024 10.1016/j.chest.2024.02.013. PMID: 38360172.
  2. Werder et al. The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. The American Journal of Human Genetics. 2023 10.1016/j.ajhg.2023.08.017. PMID: 37734371.
  3. Kaserman et al. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin deficiency heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell Reports. 2022; 10.1016/j.celrep.2022.111775. PMID: 36476855.
  4. Werder et al. CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells. Science Advances. 2022; 10.1126/sciadv.abo6566. PMID: 36476855.
  5. Abo et al. Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epithelium. JCI Insight. 2022; PMID: 35315362.
  6. Werder RB et al. Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient iPSC-hepatocytes. Molecular Therapy. 2021 Nov 3. PMID: 34217893.
  7. Heckman RM et al. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Molecular Cell. 2020 Dec 17. PMID: 33259812.
  8. Huang J et al. SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. Cell Stem Cell. 2020 Dec 3. PMID: 32979316.
  9. Kaserman JE et al. A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells. Stem Cell Reports. 2020 Jul 14. PMID: 32619491.
  10. Kaserman JE et al. Protocol for Directed Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) to a Hepatic Lineage. Methods Mol. Biol. 2017. PMID: 28752455.
  11. Payne JG et al. Multilineage Transduction of Resident Lung Cells in vivo by AAV2/8 for α1-Antitrypsin Gene Therapy. Molecular Therapy, Methods & Clinical Development. 2016 Jun 29. PMID: 27408904.
  12. Wilson AA et al. Emergence of a Stage-Dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-Deficient iPS Cells. Stem Cell Reports. 2015 Apr 2. PMCID: PMC4437473.
  13. Wilson AA et al. Lentiviral Delivery of RNAi for In Vivo Lineage-Specific Modulation of Gene Expression in Mouse Lung Macrophages. Molecular Therapy. 2013 Feb. PMCID: PMC3616534.
  14. Wilson AA et al. Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. Journal of Clinical Investigation. 2010 Jan. PMID: 20038801.
  15. Wilson AA et al. Sustained Expression of α1-Antitrypsin after Transplantation of Manipulated Hematopoietic Stem Cells. American Journal of Respiratory Cell Molecular Biology. 2008 Aug. PMID: 18323534.